De Soto was one of four principle towns established in Clarke County before the American Civil War. Established along the Chickasawhay River before the arrival of the Mobile and Ohio Railroad, construction of housing in De Soto may have started as early as 1845 and by 1858 churches were being erected. The town had a Post Office and two churches in 1900 when the population was 258.
In 1855, the Mobile and Ohio Railroad laid track and built a train station at De Soto.
A post office operated under the name De Soto from 1856 to 1978.
At one point, De Soto was home to two sawmills, a drug store, a hotel, a blacksmith, and multiple general stores.
Founding dates: Wikidata, Wikipedia, the U.S. post office records of Blevins & Helbock (CC0) and the Census. Homes by year built: Census ACS 2020–24. National Register of Historic Places: National Park Service (list of May 22, 2026). Old photos, postcards and papers: Wikimedia Commons, the Library of Congress and other public archives, credited on each item’s page. Maps: U.S. Geological Survey historical topographic maps (via Esri) and Sanborn fire-insurance maps (Library of Congress). History text and census tables: Wikipedia (CC BY-SA 4.0). Places that used to be: USGS Geographic Names Information System (2021). How TownRatings grades history →
From the National Register of Historic Places (2), Wikipedia, U.S. Geological Survey historical maps, the US Post Offices dataset (Blevins & Helbock) and the USGS Geographic Names Information System. Archive images are copied here with their credits and licenses, shown on each photo’s page. Refreshed monthly.