Humansville was named after an American settler James Human who settled in the area in 1834. A post office called Humansville has been in operation since 1839.
During the Civil War, a skirmish was fought on the town's outskirts on March 26, 1862, in which approximately 300 to 400 Missouri Confederates under Col. James M. Frazier of Cedar County clashed with two companies of pro-Union Missouri State Militia. Casualties were few, but Col. Frazier was himself mortally wounded, which caused the Confederates to retreat.
The George Dimmitt Memorial Hospital was listed on the National Register of Historic Places in 2012.
Founding dates: Wikidata, Wikipedia, the U.S. post office records of Blevins & Helbock (CC0) and the Census. Homes by year built: Census ACS 2020–24. National Register of Historic Places: National Park Service (list of May 22, 2026). Old photos, postcards and papers: Wikimedia Commons, the Library of Congress and other public archives, credited on each item’s page. Maps: U.S. Geological Survey historical topographic maps (via Esri) and Sanborn fire-insurance maps (Library of Congress). History text and census tables: Wikipedia (CC BY-SA 4.0). Places that used to be: USGS Geographic Names Information System (2021). How TownRatings grades history →
From Wikimedia Commons (4), the National Register of Historic Places (1), Wikipedia, Wikidata and Wikipedia for famous people, U.S. Geological Survey historical maps, U.S. Census counts (via Wikipedia), the US Post Offices dataset (Blevins & Helbock), the USGS Geographic Names Information System and Sanborn fire insurance maps (Library of Congress). Archive images are copied here with their credits and licenses, shown on each photo’s page. Refreshed monthly.